Mixwell Compounding Pharmacy in Chino, CA prepares compounded enclomiphene citrate capsules for men with secondary hypogonadism — a prescription-only oral alternative for physicians seeking to restore testosterone levels while preserving the patient's natural hormonal axis and fertility potential.
Key distinction: Unlike traditional testosterone replacement therapy (TRT), enclomiphene works by stimulating the body's own testosterone production through pituitary activation — rather than supplying external testosterone. This means testicular function and spermatogenesis may be preserved, making it a consideration for men with secondary hypogonadism who wish to maintain fertility.
What Is Enclomiphene?
Enclomiphene citrate is the trans-isomer of clomiphene — a selective estrogen receptor modulator (SERM) that blocks estrogen receptors at the hypothalamus and pituitary. This blockade removes negative feedback on the HPG axis, prompting increased release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which in turn stimulate the testes to produce testosterone endogenously.
Enclomiphene is not currently FDA-approved as a standalone drug product. The only legal way to access it in the U.S. is through a compounding pharmacy with a valid prescription from a licensed healthcare provider. Mixwell compounds enclomiphene citrate capsules to the exact strength specified on your physician's prescription.
Enclomiphene vs. Clomiphene vs. TRT
Clomiphene (Clomid)
- Contains both cis- and trans-isomers
- Cis-isomer (zuclomiphene) has estrogenic activity
- May cause mood changes, hot flashes, visual disturbances
- Commercially available; longer half-life means accumulation
Enclomiphene (compounded)
- Trans-isomer only — purer anti-estrogenic SERM action
- Fewer estrogenic side effects than clomiphene
- Preserves spermatogenesis and fertility potential
- Shorter half-life — less accumulation, cleaner washout
Testosterone Replacement Therapy (TRT)
- Supplies external testosterone directly
- Suppresses LH/FSH — reduces natural production
- Associated with testicular atrophy and infertility
- Multiple FDA-approved forms available
Enclomiphene (compounded)
- Stimulates endogenous testosterone production
- Preserves HPG axis and testicular function
- Fertility-friendly alternative for eligible patients
- Oral capsule — no injections or topical application
Why Some Physicians Prescribe Compounded Enclomiphene
Endogenous production
Stimulates the body's own testosterone rather than replacing it externally — preserving the natural hormonal axis.
Fertility preservation
Unlike TRT, enclomiphene maintains LH and FSH signaling, supporting spermatogenesis for men with fertility goals.
Oral convenience
A once-daily oral capsule — no injections, gels, patches, or skin transfer risk.
Fewer estrogenic effects
Isolating the trans-isomer removes the estrogenic activity associated with the cis-isomer in clomiphene.
Custom strength
Common clinical doses of 6.25 mg, 12.5 mg, and 25 mg compounded exactly to your physician's prescription.
What the Evidence Shows
A 2024 systematic review and meta-analysis in Translational Andrology and Urology found that SERM therapy (including enclomiphene and clomiphene) significantly improved total testosterone versus placebo — mean difference of 273.76 ng/dL (95% CI: 191.87–355.66 ng/dL; p<0.01) — with no statistically significant difference compared to testosterone gel groups.
A phase II/III clinical program assessed enclomiphene at 12.5 mg and 25 mg daily in men with secondary hypogonadism, demonstrating significant increases in total testosterone while maintaining LH, FSH, and sperm counts — in contrast to TRT, which suppressed gonadotropins and sperm counts in the same study population.
Evidence from small clinical studies indicates that enclomiphene achieves testosterone levels comparable to transdermal TRT while maintaining spermatogenesis and showing reduced rates of adverse effects such as mood changes and decreased libido.
Enclomiphene is not FDA-approved. Long-term safety and efficacy data are still being developed. Your physician determines whether enclomiphene is appropriate based on your individual clinical presentation, diagnosis, and treatment goals.
Prescription required. Enclomiphene is a prescription-only compounded medication. Mixwell does not compound or dispense without a valid prescription from a licensed physician. This is not an FDA-approved drug product. Regular laboratory monitoring — including testosterone, LH, FSH, estradiol, and hematologic parameters — is recommended by prescribers during therapy.
Monitoring Protocol (Prescriber Reference)
Published clinical programs typically initiate enclomiphene at 12.5 mg daily, reassessing at approximately 6 weeks with up-titration to 25 mg daily if morning total testosterone remains sub-therapeutic. Recommended monitoring includes total testosterone, LH, FSH, estradiol, hematocrit/hemoglobin, and lipids — with semen analyses when fertility is a treatment goal. Your clinical protocol may differ based on patient-specific factors.
Our Compounding Standards
Mixwell Compounding Pharmacy is a PCCA member pharmacy and state-licensed California non-sterile compounding pharmacy. All enclomiphene capsules are prepared by licensed pharmacists using pharmaceutical-grade enclomiphene citrate to the exact strength and quantity on your prescription. We operate under USP 795 / 800 non-sterile compounding standards and full California Board of Pharmacy compliance.
How to Get Started
- Consult your physician for evaluation and laboratory testing confirming secondary hypogonadism. Discuss whether enclomiphene is appropriate for your clinical situation and fertility goals.
- Obtain a prescription specifying enclomiphene citrate capsules — including strength (commonly 12.5 mg or 25 mg), quantity, and dosing frequency.
- Call Mixwell at (909) 378-7301 to confirm formulation details and current turnaround time.
- Pick up at our Chino, CA pharmacy or ask about California delivery options.
Serving Patients & Prescribers Across the Inland Empire & Southern California
Frequently Asked Questions
What is the difference between enclomiphene and clomiphene?
Clomiphene contains two isomers: enclomiphene (trans) and zuclomiphene (cis). The cis-isomer has estrogenic activity that may contribute to side effects such as mood changes, hot flashes, and gynecomastia. Enclomiphene isolates the trans-isomer, which acts as a pure estrogen receptor antagonist at the hypothalamus and pituitary — resulting in a cleaner SERM profile with fewer estrogenic side effects in clinical studies.
Can enclomiphene be used by men who want to preserve fertility?
Unlike TRT, which suppresses LH and FSH and can reduce sperm production, enclomiphene stimulates gonadotropin release and has been shown to maintain spermatogenesis in clinical studies. Whether enclomiphene is appropriate for a specific patient's fertility goals is determined by their prescribing physician and, in some cases, a reproductive urologist or endocrinologist.
Is enclomiphene FDA-approved?
No. Enclomiphene citrate is not currently an FDA-approved drug product. It is available only through compounding pharmacies with a valid physician prescription. Mixwell compounds enclomiphene under California Board of Pharmacy regulations and USP <795> standards.
What strengths does Mixwell compound?
We compound enclomiphene to the exact strength specified on your physician's prescription. Commonly referenced clinical doses include 6.25 mg, 12.5 mg, and 25 mg daily. Your physician determines the appropriate starting dose and titration schedule.
What monitoring is needed during enclomiphene therapy?
Your physician determines the monitoring schedule. Published clinical programs recommend baseline and follow-up laboratory testing including total testosterone, LH, FSH, estradiol, and hematologic parameters at approximately 6-week intervals initially, then every 3–6 months once stable. Semen analyses are recommended when fertility preservation is a goal.
Does Mixwell accept insurance?
Mixwell Compounding Pharmacy does not accept insurance. Call (909) 378-7301 for current pricing information.
How long does compounding take?
Most enclomiphene capsule formulations are ready within 1–3 business days. Call us for current turnaround times.
Mixwell Compounding Pharmacy
13788 Roswell Ave, Ste 158 · Chino, CA 91710
PCCA Member · CA Licensed · USP <795> · Rx Required · No Insurance Accepted
📞 Call (909) 378-7301References: Wiehle R, et al. Testosterone restoration by enclomiphene citrate in men with secondary hypogonadism. BJU Int. 2013;112(8):1188-1200. | Saffati G, et al. Safety and efficacy of enclomiphene and clomiphene for hypogonadal men. Transl Androl Urol. 2024;13(9):1984-1990. | Rodriguez KM, et al. Enclomiphene citrate for the treatment of secondary male hypogonadism. Expert Opin Pharmacother. 2016. | BSSM Position Statement on Enclomiphene in Male Hypogonadism. World J Men's Health. 2025. | Systematic review: Clomiphene or enclomiphene citrate for male hypogonadism. PMC. 2024. | Reviewed by Mixwell Compounding Pharmacy licensed pharmacist team, Chino, CA.