Mouth rinseOral mucosalNon sterile Rx only

"Magic Mouthwash"

Oral Rinse Vehicle

A compounded oral rinse combining ingredients such as an antihistamine, a local anesthetic, and an antacid, prepared to each prescriber's exact order.

Reviewed by Linda Pungpravat, Compounding Pharmacist, RPh Mixwell Compounding Pharmacy, Chino, CA

USP <795> compliant
USP <800> hazardous drug lab
PCCA member

At a Glance

Preparation details for "Magic Mouthwash"
Dosage form	Mouth rinse
Route	Oral mucosal
Active ingredients	Diphenhydramine, Lidocaine, Aluminum hydroxide / magnesium hydroxide
Technology	Oral Rinse Vehicle
Commercial product	No U.S. commercial product
Strength and directions	Per prescriber
Dispensing	Valid prescription

Speak with our pharmacist Send a prescription

Phone (909) 378-7301. Fax (909) 378-7071

Clinical Advantages

Multiple actives in one base
Custom strength available
Dye free option
Alcohol free
Flavored for palatability
Pediatric friendly flavoring

How It Works

What is "Magic Mouthwash"?

"Magic Mouthwash" is a compounded oral rinse that combines several ingredients in one liquid, prepared to a prescriber's written order. It is swished in the mouth, then spit out or swallowed as directed.

How it works

Diphenhydramine is an antihistamine with anticholinergic and local numbing effects on mucous membranes [1].

Lidocaine hydrochloride is a local anesthetic labeled to numb inflamed mouth and throat tissue [2].

Aluminum hydroxide and magnesium hydroxide are antacid ingredients labeled for swallowed stomach relief [3].

Some formulas use the antacid's texture to help the mixture coat the mouth for a short time.

When prescribers choose it

Oncologists and hospice or palliative care providers managing oral discomfort during cancer treatment

Dentists and oral surgeons for post procedure oral discomfort

Primary care and pediatric practices for patients who cannot tolerate a single commercial product

Clinical Details

Why is it compounded, and how is it typically used?

Why it is compounded

No single commercial product combines these ingredients in one oral rinse. Each ingredient is sold on its own, approved for its own separate use, so a prescriber who wants a combined rinse orders it compounded.

Dosage forms and strengths

Custom combinations of ingredients set by the prescriber
Dye free, alcohol free, or sugar free versions on request
Flavoring to improve taste for children or patients with low appetite
A measured dose cup or oral syringe for accurate dosing

How Mixwell prepares it

Mixwell compounds this rinse in Chino, California under USP 795 standards for non sterile preparations. Each batch is documented and dated according to USP beyond use dating rules, and finished rinses ship across California.

Safety information

Diphenhydramine labeling warns of drowsiness and anticholinergic effects such as dry mouth [1]. Lidocaine labeling carries a boxed warning for seizures, cardiopulmonary arrest, and death in children under 3 years old when dosing instructions are not followed closely, and it should not be used for teething pain [2]. Swallowed antacid ingredients can affect patients with kidney problems [3]. No clinical studies have evaluated this specific combination as a single rinse, and no FDA approved product combines these ingredients this way. Patient selection, dosing, and monitoring are the prescriber's responsibility.

References

[1] Diphenhydramine Hydrochloride Oral Solution. FDA label (DailyMed). https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=6fe6fe2d-4405-4e7a-a2ed-5eb367d52842

[2] Lidocaine Hydrochloride Oral Topical Solution, USP, 2% (Viscous). FDA label (DailyMed). https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=79b42076-359d-4258-b1d8-f40e67ac5424

[3] Antacid (Aluminum Hydroxide, Magnesium Hydroxide, Simethicone) Suspension. FDA label (DailyMed). https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e2a14762-3860-44c3-a3ea-5dbc45f4b1d5

What to include on the prescription

APIs and strengths
Base or vehicle
Quantity
Directions for use
Refills
Allergies or dye free needs

Call (909) 378-7301 Fax (909) 378-7071

Compounded in Chino, CA. Delivered across California.

Chino
Chino Hills
Ontario
Pomona
Diamond Bar
Rancho Cucamonga
Eastvale

Mixwell Compounding Pharmacy 13788 Roswell Ave, Ste 158, Chino, CA 91710
(909) 378-7301

Compounded medications are not reviewed or approved by the FDA. Dispensed only with a valid prescription. Mixwell is a non sterile pharmacy and does not prepare sterile products or injectables. Compounded preparations are not presented as superior to commercially available products, and nothing here promises a specific result. Mixwell does not accept insurance. Call for pricing.

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