Mixwell Compounding Pharmacy in Chino, CA prepares custom Ketoprofen-Gabapentin Transdermal Cream — a physician-prescribed topical formulation designed to deliver anti-inflammatory and neuropathic pain agents directly to the affected area, without requiring oral administration. Serving prescribers and patients across all of California.
Who This Formulation Is Typically Prescribed For
🩺 For Prescribers
- Rheumatology practices managing chronic joint pain
- Primary care physicians treating osteoarthritis
- Patients with GI intolerance to oral NSAIDs
- Adults 50+ where systemic NSAID risk is elevated
- Patients on anticoagulants or with renal considerations
🌿 For Patients
- Chronic joint or arthritis pain in a localized area
- History of GI upset, ulcers, or GI bleeds from oral NSAIDs
- Preference for a topical, non-oral treatment option
- Osteoarthritis of the knee, hand, shoulder, or hip
How the Two Ingredients Work
Ketoprofen
A propionic acid NSAID. Applied topically, it penetrates to local tissues and inhibits prostaglandin synthesis to reduce inflammation and pain at the application site.
Gabapentin
An anticonvulsant that modulates calcium channels involved in neuropathic pain signaling. Included in formulations targeting mixed nociceptive and neuropathic pain components.
Transdermal base
The compounded cream base is selected by the prescribing pharmacist to support skin absorption and deliver active ingredients to target tissues as prescribed.
⚖️ Why Topical vs. Oral NSAIDs May Be Prescribed
- Topical administration delivers drug locally with significantly lower systemic bioavailability — generally less than 5% compared to equivalent oral doses, per published pharmacokinetic data.
- Topical NSAIDs do not significantly increase gastrointestinal adverse events compared to placebo in meta-analyses of osteoarthritis trials, unlike oral NSAIDs which carry well-documented GI, cardiovascular, and renal risks.
- Evidence-based guidelines recommend topical NSAIDs as a first-line option for localized musculoskeletal pain, particularly in older adults and those with GI risk factors.
- Ketoprofen demonstrates higher skin permeability than many other topical NSAIDs in comparative preclinical studies, supporting its use in transdermal formulations.
What the Evidence Says
Published research on compounded multi-ingredient topical pain creams has produced mixed findings. A randomized controlled trial by Brutcher et al. (2019) published in Annals of Internal Medicine found no statistically significant difference in average pain scores between compounded topical pain creams and placebo at one month in patients with chronic localized pain. The authors noted that ingredients with the most individual evidence for topical use — particularly NSAIDs like ketoprofen — may have contributed to a numerically small difference in favor of the active creams.
Separately, a Cochrane meta-analysis found topical NSAIDs more effective than placebo for chronic musculoskeletal pain, with topical ketoprofen showing no increase in serious adverse events and no increase in GI adverse events compared to placebo.
Mixwell compounds this formulation based on a valid physician prescription. Your prescriber determines whether this formulation is appropriate for your individual clinical situation based on your history, examination, and treatment goals.
Prescription required. Mixwell does not compound or dispense any medication without a valid prescription from a licensed physician or authorized prescriber. This formulation is not an FDA-approved drug product. It is prepared individually based on your prescription.
Our Compounding Standards
Mixwell Compounding Pharmacy is a PCCA member pharmacy and state-licensed California non-sterile compounding pharmacy. Our licensed pharmacists review every prescription before compounding begins, use pharmaceutical-grade active ingredients, and select appropriate bases for each individual formulation.
We operate in full compliance with California Board of Pharmacy regulations and USP <795> non-sterile compounding standards.
For Prescribers: How to Send a Prescription
- Write a prescription specifying Ketoprofen and Gabapentin concentrations, base type, quantity, and application instructions.
- Fax or send the prescription to Mixwell Compounding Pharmacy in Chino, CA.
- Call (909) 378-7301 to confirm receipt, discuss formulation options, and verify turnaround time.
- Your patient picks up at our Chino pharmacy or contacts us about California delivery options.
Serving All of California
Frequently Asked Questions
Do I need a prescription for compounded Ketoprofen-Gabapentin cream?
Yes. All compounded medications require a valid prescription from a licensed physician or authorized prescriber. Mixwell does not compound or dispense without a verified prescription on file.
How is this cream applied?
Application site, frequency, and quantity are determined by your prescribing physician and specified on the prescription label. Follow your physician's instructions exactly.
Is compounded transdermal cream the same as FDA-approved topical diclofenac?
No. Compounded preparations are not FDA-approved drug products. They are prepared individually based on a physician prescription. Commercially available topical diclofenac (e.g., Voltaren Gel) is FDA-approved for osteoarthritis pain. Your physician determines which option is appropriate for your situation.
What concentrations of ketoprofen and gabapentin can Mixwell compound?
We compound to the exact concentrations specified on your physician's prescription. Common formulations referenced in clinical literature include ketoprofen 10% with gabapentin 6%, but your physician determines the appropriate concentration for your patient's needs.
Can prescribers in other California cities send prescriptions to Mixwell?
Yes. Mixwell is a California-licensed compounding pharmacy serving patients and prescribers statewide. Call (909) 378-7301 to discuss how to send prescriptions and current turnaround times.
Does Mixwell accept insurance?
Mixwell Compounding Pharmacy does not accept insurance. Call (909) 378-7301 for current pricing information.
How long does compounding take?
Most topical cream formulations are ready within 1–3 business days. Contact us for current turnaround times.
Can I use my HSA or FSA to pay for compounded medications?
Yes, you should be able to charge your compounded medications to your HSA or FSA account; however, we cannot charge veterinary prescriptions to these accounts. Call (909) 378-7301 for pricing.
Mixwell Compounding Pharmacy
13788 Roswell Ave, Ste 158 · Chino, CA 91710
PCCA Member · CA Licensed · USP 795 800 · Serving All of California · No Insurance Accepted
📞 Call (909) 378-7301References: Brutcher RE, et al. Compounded Topical Pain Creams to Treat Localized Chronic Pain. Ann Intern Med. 2019;170(5):309-318. | Derry S, et al. Topical NSAIDs for chronic musculoskeletal pain in adults. Cochrane Database Syst Rev. 2016. | Simon LS, et al. Topical NSAIDs in Rheumatic Diseases. Drugs. 2000;60(3):555-574. | Multidisciplinary Guidelines for the Rational Use of Topical NSAIDs for Musculoskeletal Pain. PMC. 2023. | Reviewed by Mixwell Compounding Pharmacy licensed pharmacist team, Chino, CA.