Menopause & Perimenopause Support
CreamTopicalNon sterile Rx only

Estriol Topical Cream (ExoBlue™)

Peptide and Zinc Hyaluronate Cream Base (ExoBlue™)

A compounded estriol cream in PCCA's ExoBlue base for use on the skin, prepared in Chino, CA to a prescriber's order. Not FDA approved.

Reviewed by Linda Pungpravat, Compounding Pharmacist, RPh Mixwell Compounding Pharmacy, Chino, CA

  • USP <795> compliant
  • USP <800> hazardous drug lab
  • PCCA member

Clinical Advantages

  • Custom strength available
  • Applied topically
  • Non sterile preparation

How It Works

What is estriol?

Estriol is a form of estrogen, a hormone. No FDA approved drug contains estriol. The FDA approved estrogen products applied to the skin are estradiol gels, which are labeled for moderate to severe hot flashes due to menopause, and for EstroGel also for moderate to severe vulvar and vaginal atrophy due to menopause [1][2].

What ExoBlue is, and what compounding in it provides

ExoBlue is a topical base made by PCCA. PCCA calls it a cosmetic base for skincare and anti aging use, and lists hormones among the common drug types used in it. PCCA's base page does not name estriol. Mixwell prepares estriol in ExoBlue at the strength the prescriber orders. PCCA describes ExoBlue as follows [5]:

  • A light blue, smooth cream. The blue color comes from its copper peptide
  • Built on a core system of acetyl hexapeptide 8, GHK copper peptide, zinc hyaluronate, and a Centella asiatica derived exosome and peptide complex
  • Designed to support overall skin conditioning and visible skin renewal
  • Described as enhancing hydration and supporting a balanced skin environment
  • Described as improving the appearance of fine lines, wrinkles, and skin texture
  • Light and moisturizing, for use on oily, normal, or dry skin
  • Designed to maintain peptide stability and support consistent performance

Compounding makes it possible to apply estriol to the skin in this base, at a strength the prescriber sets, because no approved product is made for that. These are the manufacturer's descriptions of a cosmetic base. They are not findings by the FDA, and they are not claims about estriol.

When prescribers choose it

  • Gynecology, menopause, and aesthetic practices that prescribe estrogen for the skin
  • Prescribers who want estriol rather than estradiol
  • Prescribers who want to set the strength

Clinical Details

What does the evidence show?
  • FDA approved estradiol gel 0.1% is labeled for the treatment of moderate to severe vasomotor symptoms due to menopause [1]. EstroGel 0.06% is labeled for moderate to severe vasomotor symptoms and for moderate to severe symptoms of vulvar and vaginal atrophy due to menopause [2].
  • HHS and the FDA describe approved menopausal hormone therapies as approved to provide relief from common menopause symptoms, such as hot flashes and night sweats [3].
  • No FDA approved drug contains estriol, and no FDA approved estrogen product is labeled for use as a skin treatment. This preparation is made in ExoBlue, which its maker describes as a cosmetic base [5]. The FDA has not reviewed this preparation.

Findings come from the cited studies and do not promise any individual outcome.

Why is it compounded, and how is it typically used?

Why it is compounded

No FDA approved product contains estriol. The approved estrogens applied to the skin are estradiol gels labeled for menopausal symptoms [1][2]. A prescriber who wants estriol applied to the skin orders it compounded.

Dosage forms and strengths

  • Strength set by the prescriber
  • ExoBlue base, a light blue cream
  • Quantities matched to the prescription

Dosing, any use with a progestogen, and monitoring are the prescriber's decision.

How Mixwell prepares it

Mixwell compounds this cream in Chino, California under USP 795 standards for non sterile preparations, in a facility with a USP 800 negative pressure containment room [6]. Our pharmacist confirms the strength and base with the prescriber before compounding. Batch records document every preparation, and finished creams ship across California.

Safety information

FDA approved estrogen gels carry a boxed warning for endometrial cancer with unopposed estrogen in women with a uterus [1]. In February 2026 the FDA approved labeling changes that removed the cardiovascular disease, breast cancer, and probable dementia language from the boxed warnings of menopausal hormone therapy products, and kept the boxed warning for endometrial cancer on systemic estrogen alone products. Information on cardiovascular disease and breast cancer stays in the labeling outside the boxed warning [3][4].

Those changes apply to FDA approved products. A compounded preparation has no FDA approved labeling. Approved estrogen gels applied to the skin are labeled to treat hot flashes, a whole body effect [1][2]. No FDA labeling states how much estriol is absorbed from a cream applied to the skin, or how the base affects it.

Tell your prescriber about your medical history and any ingredient allergies. Mixwell can provide the ingredient list for your preparation. Patient selection, dosing, and monitoring are the prescriber's responsibility.

References
  1. Estradiol gel 0.1%. Prescribing information. DailyMed. DailyMed
  2. ESTROGEL (estradiol gel) 0.06%. Prescribing information. DailyMed. DailyMed
  3. U.S. Department of Health and Human Services. Fact sheet: FDA initiates removal of black box warnings from menopausal hormone replacement therapy products. HHS
  4. U.S. Food and Drug Administration. FDA approves labeling changes to menopausal hormone therapy products. February 12, 2026. FDA
  5. ExoBlue. Product information. PCCA. PCCA product page PCCA base technologies
  6. United States Pharmacopeia. General Chapters 795 and 800. USP NF.

What to include on the prescription

  • APIs and strengths
  • Base or vehicle
  • Quantity
  • Directions for use
  • Refills
  • Allergies or dye free needs
Call (909) 378-7301 Fax (909) 378-7071

Related Solutions

Bi-Est Cream (Estriol / Estradiol) Compounded BHRTCREAM Tretinoin Topical Cream (ExoBlue™)CREAM Tranexamic Acid 3% Topical Cream (ExoBlue™)CREAM Commonly prescribed for Menopause & Perimenopause Support

Compounded in Chino, CA. Delivered across California.

  • Chino
  • Chino Hills
  • Ontario
  • Pomona
  • Diamond Bar
  • Rancho Cucamonga
  • Eastvale
Mixwell Compounding Pharmacy 13788 Roswell Ave, Ste 158, Chino, CA 91710
(909) 378-7301

Compounded medications are not reviewed or approved by the FDA. Dispensed only with a valid prescription. Mixwell is a non sterile pharmacy and does not prepare sterile products or injectables. Compounded preparations are not presented as superior to commercially available products, and nothing here promises a specific result. Mixwell does not accept insurance. Call for pricing.

Call pharmacist Send Rx

Want to learn more about Estriol Topical Cream (ExoBlue™)

Are you a healthcare provider or patient in Chino, Chino Hills, Ontario, Eastvale, Rancho Cucamonga, or Upland? Mixwell Pharmacy provides specialized pharmaceutical support throughout San Bernardino, Los Angeles, and Orange Counties. Contact our Chino laboratory to learn how we facilitate customized Estriol Topical Cream (ExoBlue™)for practitioners across Southern California.

(909) 378-7301

Serving Los Angeles County, Orange County, San Bernardino County, Riverside County, Ventura County, and the Inland Empire