Integrative & Personalized Medicine

Nasal Support

Also called chronic sinusitis, chronic rhinosinusitis, CRS, persistent sinus infection

Chronic sinusitis is common, and saline rinses and steroid sprays come first. When a nasal specialist orders a medicated spray, Mixwell in Chino, CA prepares it.

Signs people notice

  • A blocked or stuffy nose
  • Thick nasal drainage, or drainage down the back of the throat
  • Pressure or pain in the face
  • A reduced or lost sense of smell
  • Tiredness
  • Poor sleep
  • Trouble concentrating
  • Symptoms that last three months or longer

Clinical Overview

What is chronic sinusitis?

Chronic sinusitis, also called chronic rhinosinusitis, is long lasting inflammation of the nose and sinuses. It is diagnosed when at least two of four main symptoms last three months or longer and an exam or scan shows inflammation [1]. The four symptoms are a blocked or congested nose, nasal drainage, facial pain or pressure, and a reduced sense of smell [1].

How it affects daily life

Besides nose symptoms, chronic sinusitis can cause tiredness, poor sleep, trouble concentrating, and low mood [1].

What is tried first

First line treatment is saline rinses and steroid nose sprays [1]. Rinses of more than 60 mL work better than sprays, with full benefit by about 8 weeks [1]. Decongestant sprays are not recommended, because they can cause rebound congestion [1]. Short courses of antibiotics by mouth are not recommended either [1]. The 2021 international sinus guideline also recommends against routine topical antibiotics and topical antifungals [2].

When surgery is considered

A referral for surgery is considered if symptoms continue after at least 3 to 4 weeks, and preferably 8 weeks, of first line treatment [1]. Surgery opens the sinus drainage pathways, which also helps topical medicines reach the sinuses [1].

How Compounding Can Help

Most chronic sinusitis is managed with saline rinses and steroid sprays that are widely available [1]. Guidelines recommend against routine topical antibiotics and antifungals [2]. When a nasal specialist orders a medicated spray that no commercial product offers, a compounding pharmacy can prepare it.

  • A nasal spray with gentamicin, itraconazole, mupirocin, and edetate disodium in MucoLox, a mucoadhesive base designed to cling to the lining of the nose
  • Usually ordered by an ear, nose, and throat specialist for sinusitis that persists after sinus surgery, guided by a culture
  • Strengths set by the prescriber

This is a specialist decision, not a first step. Your specialist decides whether it fits your situation.

Common Formulas Prescribers Order for This

Each formula is prepared only with a valid prescription. Your prescriber decides what is appropriate.

What to ask your provider

  • How long have my symptoms lasted, and do they fit chronic sinusitis?
  • Do I need a nasal exam or a CT scan to confirm it?
  • Am I rinsing and using a steroid spray the right way, and for long enough?
  • Could allergies, polyps, or another condition be involved?
  • Should I be seen by an ear, nose, and throat specialist?
  • If I have had sinus surgery, is a culture needed before any antibiotic or antifungal treatment?
Call (909) 378-7301

Common Questions

What is chronic sinusitis?

Chronic sinusitis, also called chronic rhinosinusitis, is long lasting inflammation of the nose and sinuses. It is diagnosed when at least two of four symptoms last three months or longer: a blocked nose, nasal drainage, facial pain or pressure, and a reduced sense of smell. An exam or scan also shows inflammation.

What helps chronic sinusitis first?

Saline rinses and steroid nose sprays are the first line treatments. Rinses of more than 60 mL work better than sprays, with full benefit by about 8 weeks. Decongestant sprays are not recommended because they can cause rebound congestion. If symptoms continue, your provider may refer you to an ear, nose, and throat specialist.

Do antibiotics help chronic sinusitis?

Short courses of antibiotics by mouth are not recommended for chronic sinusitis, even during flare ups, because they have not been shown to help. The 2021 international sinus guideline also recommends against routine antibiotic or antifungal nose sprays. A specialist may use them in select cases, such as after sinus surgery when a culture shows a specific infection.

Do I need a prescription for a compounded medication?

Yes. Every compounded preparation is made for one patient with a valid prescription from a licensed prescriber, such as a physician, nurse practitioner, dentist, or veterinarian. If you do not have one yet, ask your provider whether a compounded preparation fits your situation, and they can send the order to us.

References
  1. Keating MK, Phillips JC, Phillips J. Chronic rhinosinusitis. Am Fam Physician. 2023;108(4):370 to 377. AAFP
  2. Orlandi RR, Kingdom TT, Smith TL, et al. International consensus statement on allergy and rhinology: rhinosinusitis 2021. Int Forum Allergy Rhinol. 2021;11(3):213 to 739. doi:10.1002/alr.22741

Compounded in Chino, CA. Delivered across California.

  • Chino
  • Chino Hills
  • Ontario
  • Pomona
  • Diamond Bar
  • Rancho Cucamonga
  • Eastvale
Mixwell Compounding Pharmacy 13788 Roswell Ave, Ste 158, Chino, CA 91710
(909) 378-7301

Mixwell is a state licensed, non sterile compounding pharmacy and a PCCA member, preparing each formula in a lab built to USP 795 and USP 800 standards. Compounded medications are not reviewed or approved by the FDA and are dispensed only with a valid prescription. We do not prepare sterile products or injectables. Nothing here promises a specific result, and compounded preparations are not presented as superior to commercially available products. Mixwell does not accept insurance. Call for pricing.