CreamTopicalNon sterile Rx only

Hydroquinone / Kojic Acid / Hydrocortisone / Tretinoin Topical Cream

Topical Cream Base

Hydroquinone, kojic acid, hydrocortisone, and tretinoin topical cream compounded in customizable bases for dermatologist directed skin care plans.

Reviewed by Linda Pungpravat, Compounding Pharmacist, RPh Mixwell Compounding Pharmacy, Chino, CA

USP <795> compliant
USP <800> hazardous drug lab
PCCA member

At a Glance

Preparation details for Hydroquinone / Kojic Acid / Hydrocortisone / Tretinoin Topical Cream
Dosage form	Cream
Route	Topical
Active ingredients	Hydroquinone, Kojic Acid, Hydrocortisone, Tretinoin
Technology	Topical Cream Base
Strengths in literature	Hydroquinone 6%; Kojic Acid 6%; Hydrocortisone 0.5%; Tretinoin 0.025%
Commercial product	Commercial product in fixed strengths only
Strength and directions	Per prescriber
Dispensing	Valid prescription

Speak with our pharmacist Send a prescription

Phone (909) 378-7301. Fax (909) 378-7071

Clinical Advantages

Multiple actives in one base
Custom strength available
Applied topically
Dye free option
Fragrance free
Non sterile preparation

How It Works

What is Hydroquinone / Kojic Acid / Hydrocortisone / Tretinoin Topical Cream?

Hydroquinone / Kojic Acid / Hydrocortisone / Tretinoin Topical Cream is a compounded dermatology preparation that combines four active ingredients in a customized topical base. It is prepared pursuant to a prescription and allows dermatologists and other licensed prescribers to specify strengths, ingredients, and base selection.

How it works

Hydroquinone inhibits melanin production pathways. Kojic acid interferes with tyrosinase activity involved in pigmentation. Hydrocortisone provides topical corticosteroid activity. Tretinoin influences epidermal cell turnover. The selected compounding base supports topical application.

When prescribers choose it

Dermatologists seeking customized topical formulations. Aesthetic medicine practices requiring individualized strengths. Functional and integrative medicine providers requesting tailored formulations. Primary care providers managing patients requiring customized topical dosage forms. Medical practices seeking specific ingredient combinations unavailable commercially.

Clinical Details

What does the evidence show?

Findings come from the cited studies and do not promise any individual outcome.

Why is it compounded, and how is it typically used?

Why it is compounded

Commercial products may not provide the exact ingredient combination, strengths, or base preferences requested by a prescriber. Compounding allows customization of formulation components and vehicle selection.

Dosage forms and strengths

Hydroquinone 6%; Kojic Acid 6%; Hydrocortisone 0.5%; Tretinoin 0.025%. Alternative strengths may be specified by the prescriber. Base selection may be tailored to patient and prescriber preference.

PCCA Base Options

WO6 Cream Base

WO6 is an oil in water cream base often selected when a lighter cream texture is desired.

Benefits: Elegant cosmetic feel; suitable for facial preparations; smooth application characteristics; customizable vehicle for multiple active ingredients.

VersaBase® Cream

VersaBase® is a versatile cream vehicle commonly used for compounded dermatology preparations.

Benefits: Broad compatibility with multiple active ingredients; smooth spreadability; consistent cream texture; frequently selected for customized dermatology prescriptions.

PermE8®

PermE8® is a permeation enhancing topical base designed for customized dermatologic preparations.

Benefits: Permeation enhancing vehicle; supports customized topical delivery strategies; compatible with multiple active ingredients; useful when prescribers request an alternative base option.

How Mixwell prepares it

Mixwell compounds this preparation in Chino, California under USP 795 standards for non sterile compounding. Beyond use dating and batch documentation follow applicable USP requirements. Prescriptions may be delivered throughout California following pharmacist verification.

Safety information

Prescribers consider patient history, skin sensitivity, application site, concurrent medications, and potential systemic absorption when selecting topical compounded formulations. Hydroquinone, hydrocortisone, and tretinoin each carry product specific precautions in commercially available products. Patient selection, dosing, and monitoring are the prescriber's responsibility.

References

DailyMed. Hydroquinone Prescribing Information.

DailyMed. Hydrocortisone Prescribing Information.

DailyMed. Tretinoin Prescribing Information.

USP General Chapter 795 Pharmaceutical Compounding Nonsterile Preparations.

What to include on the prescription

APIs and strengths
Base or vehicle
Quantity
Directions for use
Refills
Allergies or dye free needs

Call (909) 378-7301 Fax (909) 378-7071

Compounded in Chino, CA. Delivered across California.

Chino
Chino Hills
Ontario
Pomona
Diamond Bar
Rancho Cucamonga
Eastvale

Mixwell Compounding Pharmacy 13788 Roswell Ave, Ste 158, Chino, CA 91710
(909) 378-7301

Compounded medications are not reviewed or approved by the FDA. Dispensed only with a valid prescription. Mixwell is a non sterile pharmacy and does not prepare sterile products or injectables. Compounded preparations are not presented as superior to commercially available products, and nothing here promises a specific result. Mixwell does not accept insurance. Call for pricing.

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