Compounding Services
CreamTopicalNon sterile Rx only

Tofacitinib Compounded Topical Cream

Topical Cream Base

Tofacitinib compounded into a topical cream in Chino, CA. Prescribers set the strength and base. Not FDA approved. Ships across California.

Reviewed by Linda Pungpravat, PharmD, RPh Mixwell Compounding Pharmacy, Chino, CA. Updated

  • USP <795> compliant
  • USP <800> hazardous drug lab
  • PCCA member

Clinical Advantages

  • Custom strength available
  • Dye free option
  • No U.S. commercial equivalent
  • Non sterile preparation
  • Applied topically

How It Works

What is tofacitinib compounded topical cream?

Tofacitinib compounded topical cream is a made to order cream with one active ingredient. Tofacitinib is a Janus kinase (JAK) inhibitor. The prescriber sets the strength, and Mixwell prepares the cream for one patient.

What the FDA labels say

  1. FDA approved tofacitinib products are oral tablets, extended release tablets, and oral solution. The XELJANZ label lists rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and ulcerative colitis among its adult indications [1].
  2. The label describes oral use. It does not describe topical use [1].

When prescribers choose it

  • Dermatology practices that order a topical tofacitinib preparation
  • Prescribers who need a strength or base no commercial product offers
  • Prescribers whose patients need a dye free or custom base

Clinical Details

What does the evidence show?
  • DailyMed lists tofacitinib labeling for oral tablets, extended release tablets, and oral solution. The XELJANZ label lists rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and ulcerative colitis among its indications [1].
  • A search of DailyMed tofacitinib listings (38 labels, checked November 1, 2026) shows no cream, ointment, gel, or other topical product [1].
  • FDA states that compounded drugs are not FDA approved, and that FDA does not review them for safety, effectiveness, or quality before they reach patients. Section 503A requires a valid prescription for a patient [2].

Findings come from the cited studies and do not promise any individual outcome.

Why is it compounded, and how is it typically used?

Why it is compounded

DailyMed lists no topical tofacitinib product. Approved tofacitinib products are oral tablets, extended release tablets, and oral solution [1]. A prescriber who wants tofacitinib as a topical cream orders it from a compounding pharmacy.

Dosage forms and strengths

  • Tofacitinib strength set by the prescriber
  • Cream base chosen with the prescriber
  • Dye free and preservative conscious versions on request
  • Quantity matched to the prescription

Dosing and duration are the prescriber's decision.

How Mixwell prepares it

Mixwell compounds this cream in Chino, California under USP 795 standards for non sterile preparations [3]. Our pharmacist confirms the strength and base with the prescriber before compounding. Beyond use dating and batch records follow USP requirements, and finished creams ship across California.

Safety information

The XELJANZ label carries a boxed warning for serious infections, mortality, malignancies, major adverse cardiovascular events, and thrombosis. It advises testing for latent tuberculosis, and it lists upper respiratory tract infection, nasopharyngitis, diarrhea, and headache among the most common reactions in arthritis trials [1]. That label covers oral use. No FDA labeling describes how much tofacitinib is absorbed from a topical cream. Prescribers consider medical history and interacting medications. Patient selection, dosing, and monitoring are the prescriber's responsibility.

References
  1. XELJANZ (tofacitinib) tablets, oral solution. Prescribing information. DailyMed, National Library of Medicine. Updated July 12, 2026. DailyMed record
  2. U.S. Food and Drug Administration. Compounding laws and policies, including FD&C Act section 503A. fda.gov
  3. United States Pharmacopeia. General Chapter 795, Pharmaceutical Compounding: Nonsterile Preparations. USP NF. Official November 1, 2023.

What to include on the prescription

  • APIs and strengths
  • Base or vehicle
  • Quantity
  • Directions for use
  • Refills
  • Allergies or dye free needs
Call (909) 378-7301 Fax (909) 378-7071

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Compounded in Chino, CA. Delivered across California.

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Mixwell Compounding Pharmacy 13788 Roswell Ave, Ste 158, Chino, CA 91710
(909) 378-7301

Compounded medications are not reviewed or approved by the FDA. Dispensed only with a valid prescription. Mixwell is a non sterile pharmacy and does not prepare sterile products or injectables. Compounded preparations are not presented as superior to commercially available products, and nothing here promises a specific result. Mixwell does not accept insurance. Call for pricing.

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