CreamTopicalNon sterile Rx only

Hydroquinone / Tretinoin / Hydrocortisone Topical

Topical Base

Hydroquinone, tretinoin, and hydrocortisone topical cream compounded in customizable bases for dermatologist directed personalized prescriptions.

Reviewed by Linda Pungpravat, Compounding Pharmacist, RPh Mixwell Compounding Pharmacy, Chino, CA

USP <795> compliant
USP <800> hazardous drug lab
PCCA member

At a Glance

Preparation details for Hydroquinone / Tretinoin / Hydrocortisone Topical
Dosage form	Cream
Route	Topical
Active ingredients	Hydroquinone, Tretinoin, Hydrocortisone
Technology	Topical Base
Strengths in literature	Hydroquinone 4% to 8%; Tretinoin 0.025% to 0.05%; Hydrocortisone 0.5% to 1%
Commercial product	Commercial product in fixed strengths only
Strength and directions	Per prescriber
Dispensing	Valid prescription

Speak with our pharmacist Send a prescription

Phone (909) 378-7301. Fax (909) 378-7071

Clinical Advantages

Multiple actives in one base
Custom strength available
Applied topically
Dye free option
Fragrance free
Non sterile preparation

How It Works

What is Hydroquinone / Tretinoin / Hydrocortisone Topical Cream?

Hydroquinone / Tretinoin / Hydrocortisone Topical Cream is a compounded dermatology preparation containing three active ingredients in a customized topical vehicle. The formulation is prepared pursuant to a prescription and allows prescribers to select ingredient strengths and base options that are not commercially available in a single standardized product.

How it works

Hydroquinone affects pathways involved in melanin production.
Tretinoin influences epidermal cell turnover.
Hydrocortisone provides topical corticosteroid activity.
The selected cream base serves as the vehicle for topical application.
Base selection may be customized according to prescriber preference.

When prescribers choose it

Dermatologists requesting customized ingredient combinations. Medical aesthetic practices requiring individualized strengths. Functional medicine providers seeking personalized formulations. Primary care providers prescribing customized topical medications. Nurse practitioners and physician assistants managing dermatology patients.

Clinical Details

What does the evidence show?

Findings come from the cited studies and do not promise any individual outcome.

Why is it compounded, and how is it typically used?

Why it is compounded

Commercial products may not offer the exact ingredient combination, concentration, or base requested by a prescriber. Compounding allows customization of strengths and vehicle selection for individual prescriptions.

Dosage forms and strengths

Custom hydroquinone strengths specified by the prescriber. Custom tretinoin strengths specified by the prescriber. Custom hydrocortisone strengths specified by the prescriber. Dye free and fragrance free options may be available. Alternative base selection based on prescriber preference.

PCCA Base Options

WO6 Cream Base

WO6 is an oil in water cream vehicle commonly selected for cosmetic elegance and patient acceptance.

Benefits: Lightweight cream texture; suitable for facial preparations; smooth spreadability; elegant cosmetic appearance; compatible with multiple active ingredients.

VersaBase®

VersaBase® is a versatile topical cream vehicle frequently used in customized dermatology formulations.

Benefits: Broad ingredient compatibility; consistent cream texture; smooth application characteristics; flexible formulation option; frequently selected for compounded dermatology prescriptions.

PermE8®

PermE8® is a permeation enhancing topical base available for customized dermatologic preparations.

Benefits: Permeation enhancing vehicle; alternative base selection option; supports customized formulation design; compatible with multiple active ingredients; frequently utilized when prescribers request enhanced topical delivery vehicles.

How Mixwell prepares it

Mixwell compounds this preparation in Chino, California under USP 795 standards for non sterile compounding. Beyond use dating and batch documentation follow applicable USP requirements. Prescriptions may be delivered throughout California after pharmacist verification.

Safety information

Prescribers consider skin sensitivity, prior dermatologic history, concurrent medications, application area, and potential systemic exposure when selecting compounded topical formulations. Hydroquinone, tretinoin, and hydrocortisone each have product specific precautions in commercially available products. Patient selection, dosing, and monitoring are the prescriber's responsibility.

References

DailyMed. Hydroquinone Prescribing Information.

DailyMed. Tretinoin Prescribing Information.

DailyMed. Hydrocortisone Prescribing Information.

USP General Chapter 795 Pharmaceutical Compounding Nonsterile Preparations.

What to include on the prescription

APIs and strengths
Base or vehicle
Quantity
Directions for use
Refills
Allergies or dye free needs

Call (909) 378-7301 Fax (909) 378-7071

Compounded in Chino, CA. Delivered across California.

Chino
Chino Hills
Ontario
Pomona
Diamond Bar
Rancho Cucamonga
Eastvale

Mixwell Compounding Pharmacy 13788 Roswell Ave, Ste 158, Chino, CA 91710
(909) 378-7301

Compounded medications are not reviewed or approved by the FDA. Dispensed only with a valid prescription. Mixwell is a non sterile pharmacy and does not prepare sterile products or injectables. Compounded preparations are not presented as superior to commercially available products, and nothing here promises a specific result. Mixwell does not accept insurance. Call for pricing.

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